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In contrast, derepression out-of ThPOK transcription in the DP thymocytes out of ThPOKCD4.Sil mice decorative mirrors term regarding endogenous Cd4 into the DP thymocytes away from wt rats. For example, the new SilThPOK suppresses the newest transcription out of Cd4 during the DP thymocytes out of CD4ThPOK.Sil mice just like the suppression of endogenous ThPOK when you look at the DP thymocytes of wt rats. FACS analysis away from TCR?, CD69, CD4, and you may CD8 term regarding (b) complete thymocytes, gated thymocytes and you can (c) peripheral T-telephone subsets off wt mice otherwise mutant outlines, because the conveyed. Mathematical relevance are calculated for every single expressed mutant range according to wt mice. FACS data regarding TCR?, CD69, CD4, and CD8 phrase regarding overall thymocytes, gated thymocytes (c), and you will peripheral T-phone subsets (d) out of wt rats otherwise mutant traces, because expressed.
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